The reference site for Chlorpropamide

Chlorpropamide is a drug in the sulfonylurea class used to treat diabetes mellitus type 2. It is a long-acting first-generation sulfonylurea.

WHAT IS chlorpropamide?

Chlorpropamide is in a class of drugs called sulfonylureas. It works by lowering blood sugar (glucose) by increasing the release of insulin from the pancreas. (Insulin is the actual hormone that lowers the blood sugar level.)

This medicine is used to treat type 2 diabetes along with diet, exercise, and insulin therapy, if necessary.


Brand Name(s): Diabinese; Orinase; Tolinase
CAS nº: 94-20-2
(klor PROE pa mide)


Product Info

The sections below will provide you with more specific information and guidelines related to chlorpropamide and its correct use. Please read them carefully.

FDA Information

Chlorpropamide has been approved by the US Food and Drug Administration and is currently sold over the counter.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Chlorpropamide is in a class of drugs called sulfonylureas. It lowers blood sugar (glucose) by increasing the release of insulin from the pancreas. (Insulin is the hormone that lowers the blood sugar level.)

This medicine is used to treat type 2 diabetes along with diet, exercise, and insulin therapy, if necessary.

Note: approximately 90% of patients with diabetes have type II diabetes, formerly called non-insulin-dependent diabetes mellitus. Type II diabetes usually occurs in adults and is associated with obesity and a strong family history of diabetes. The inability to control blood glucose in type II diabetes is caused by reduced insulin release by the pancreas as well as decreased removal of glucose from the blood by the body’s cells.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Chlorpropamide comes in tablets that are to be administered orally.

Take chlorpropamide exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Always take each dose with a full glass of water. This medicine is usually taken before breakfast or the first main meal if it is taken once a day, or before meals if it is taken multiple times each day. Follow your doctor’s instructions.

Do not change your dose of chlorpropamide without first talking to your doctor.

It is important to take chlorpropamide regularly to get the most benefit.

Furthermore, your healthcare provider may recommend regular monitoring of blood sugar levels with blood or urine tests.

What special precautions should I follow?


Please inform your doctor if you have kidney disease, liver disease, thyroid disease, type 1 diabetes, a serious infection, illness, or injury. You may not be able to take this medicine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Do not take any prescription, over-the-counter, or herbal cough, cold, allergy, pain, or weight loss medications without first talking to your doctor.

Furthermore, many other medicines may increase or decrease the effects of chlorpropamide or affect your condition, so tell your doctor about all the medicines you are currently taking.

Patients 65 years of age and older may have a stronger reaction to chlorpropamide and may require a reduced dose.

Chlorpropamide is in the FDA pregnancy category C. This means that it is not known whether this medicine will be harmful to an unborn baby. Insulin is usually the drug of choice for controlling diabetes during pregnancy. Do not take this medicine without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Additionally, chlorpropamide passes into breast milk and may cause hypoglycemia (low blood sugar) in a nursing infant. Do not take this medicine without first talking to your doctor if you are breast-feeding a baby.

Follow diet, medication, and exercise routines closely. Changing any of these things can effect your blood sugar levels.

So too, it is advised that you avoid alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Tell your doctor and dentist that you are taking this medication before you undergo any surgery.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose.

Do not take a double dose of this medication.

What side effects can this medication cause?

Stop taking chlorpropamide and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

Other, less serious side effects from chlorpropamide result mostly from blood sugar levels that are either too high or too low. You should be familiar with the symptoms of both high and low blood sugar levels and know how to treat both conditions. Also, be sure your family and close friends know how to help you in an emergency situation.

LOW BLOOD SUGAR – this may occur when too much chlorpropamide is taken, when meals are missed or delayed, if you exercise more than usual, during illness (especially with vomiting or diarrhea), if you take other medications, after drinking alcohol, and in other situations.

Hypoglycemia or low blood sugar has the following symptoms:

cold sweats
pale, cool skin
difficulty concentrating

Keep hard, sugary candy, chocolate, fruit juice, or glucose tablets on hand to treat episodes of low blood sugar.

INCREASED BLOOD SUGAR – this, on the other hand, may occur when not enough chlorpropamide is taken, if you eat significantly more food than usual, if you exercise less than usual, if you take other medications, during fever or other illness, and in other situations.

Hyperglycemia or high blood sugar has the following symptoms:

increased thirst
increased hunger
increased urination

There may be an increased risk of death due to cardiovascular (heart and blood vessels) complications with the use of chlorpropamide when compared to the treatment of diabetes with diet or diet plus insulin. The long-term use of chlorpropamide should be discussed with your doctor.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Rememeber to throw away any medication that is outdated or no longer needed and, if necessary, please consult your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, then call the local emergency services on 911.

Symptoms of overdose may include:

cold sweats

Product Images


Below you will find images and specific information on the principal types of chlorpropamide that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Strength(s): 100 MG
Imprint: PLIVA 372
Manufacturer: PLIVA INC.

Strength(s): 100 MG
Imprint: SL 372
Manufacturer: SIDMAK LABS.

Strength(s): 250 MG
Imprint: PFIZER 394
Manufacturer: PFIZER US PHARM.

Strength(s): 250 MG
Imprint: 250 | MYLAN 210
Manufacturer: MYLAN

Strength(s): 250 MG
Imprint: PLIVA 373
Manufacturer: PLIVA INC.

Strength(s): 250 MG
Imprint: SL 373
Manufacturer: SIDMAK LABS.

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